Zhao, HaolanHaolanZhaoTeigell Beneitez, NuriaNuriaTeigell BeneitezJena, Himanshu SekharHimanshu SekharJenaSkirtach, Andre G.Andre G.Skirtachvan Der Voort, PascalPascalvan Der VoortBaets, RoelRoelBaets2025-07-312025-07-3120252378-0967WOS:001532699800002https://imec-publications.be/handle/20.500.12860/45981We report, to the best of our knowledge, the first Raman sensor for antibiotics spiked in human plasma using silicon nitride waveguides functionalized with a mesoporous silica top-cladding. Leveraging waveguiding signal enhancement, chemical enrichment, and molecular sieving, we demonstrate detection of 1 mg/l ceftazidime in plasma within 2 min. Ceftazidime quantification is achieved in plasma over 0, 20, 40, and 60 mg/l, demonstrating its potential for clinical use. Requiring minimal sample preparation, this method has great potential for point-of-need monitoring for optimal antibiotic therapy.Letter10.1063/5.0278252WOS:001532699800002BETA-LACTAM ANTIBIOTICSEVANESCENT EXCITATIONSILICONSLOTCOLLECTIONADSORPTIONFILMS