Garcia-Guzman, CeciliaCeciliaGarcia-GuzmanGarcia-Guzman, RobertoRobertoGarcia-GuzmanHorta-Velazquez, AmauriAmauriHorta-VelazquezResendiz-Ramirez, RubiRubiResendiz-RamirezCoutino-Gonzalez, EduardoEduardoCoutino-GonzalezMorales-Narvaez, EdenEdenMorales-Narvaez2026-09-282026-09-2820262052-1537https://imec-publications.be/handle/20.500.12860/60497Portable biosensing technologies are crucial for decentralized diagnostics and point-of-care applications. Conventional lateral flow assays rely on colorimetric labels, limiting sensitivity and quantification. Here, we integrate optical responsive silver cluster–zeolite composites directly functionalized with antibodies into paper-based lateral flow devices, enabling simultaneous analyte recognition and luminescent signal transduction without conjugate pads. Using human immunoglobulin G as a model analyte, the device achieves quantitative detection with high sensitivity and robustness against interfering proteins and human serum. Luminescence changes upon immunocomplex formation are captured via smartphone-based fluorescence imaging and analyzed with custom algorithms. This simplified, low-cost platform demonstrates the potential of silver cluster–zeolite composites as versatile luminescent probes for scalable, smartphone-readable, and decentralized biosensing technologies suitable for real-world diagnostics.engJournal article10.1039/d6qm00338aWOS:001828031800001