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Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

dc.contributor.authorVan den Bergh, Bram
dc.contributor.authorSchramke, Hannah
dc.contributor.authorMichiels, Joran Elie
dc.contributor.authorKimkes, Tom E. P.
dc.contributor.authorRadzikowski, Jakub Leszek
dc.contributor.authorSchimpf, Johannes
dc.contributor.authorVedelaar, Silke R.
dc.contributor.authorBurschel, Sabrina
dc.contributor.authorDewachter, Liselot
dc.contributor.authorLoncar, Nikola
dc.contributor.authorSchmidt, Alexander
dc.contributor.authorMeijer, Tim
dc.contributor.authorFauvart, Maarten
dc.contributor.authorFriedrich, Thorsten
dc.contributor.authorMichiels, Jan
dc.contributor.authorHeinemann, Matthias
dc.date.accessioned2023-05-04T13:05:42Z
dc.date.available2023-05-04T13:05:42Z
dc.date.issued2022
dc.identifier.issn2041-1723
dc.identifier.otherWOS:000749187600011
dc.identifier.urihttps://imec-publications.be/handle/20.500.12860/41558
dc.sourceWOS
dc.titleMutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis
dc.typeJournal article
dc.contributor.imecauthorFauvart, Maarten
dc.contributor.orcidextVan den Bergh, Bram::0000-0003-4429-9780
dc.contributor.orcidextMichiels, Joran Elie::0000-0003-2169-3507
dc.contributor.orcidextSchimpf, Johannes::0000-0003-3063-5026
dc.contributor.orcidextDewachter, Liselot::0000-0003-1080-1656
dc.contributor.orcidextSchmidt, Alexander::0000-0002-3149-2381
dc.contributor.orcidextFriedrich, Thorsten::0000-0002-0813-7883
dc.contributor.orcidimecFauvart, Maarten::0000-0002-6256-9193
dc.date.embargo2022-01-27
dc.identifier.doi10.1038/s41467-022-28141-x
dc.source.numberofpages18
dc.source.peerreviewyes
dc.source.beginpageArt. 546
dc.source.endpagena
dc.source.journalNATURE COMMUNICATIONS
dc.identifier.pmidMEDLINE:35087069
dc.source.issue1
dc.source.volume13
imec.availabilityPublished - open access
dc.description.wosFundingTextThe authors thank Susan Gottesman for the AB037 strain, Joan L. Slonczewski for the pHluorin plasmid, Steven B. Vik for the BA14 strain and Henri de Greve for the UTI89 strain. We further thank Ying Liu for help with cloning the plasmid for encapsulin-SpoT expression, Franziska Number for providing controls for the ACMA quenching, Alexandros Papagiannakis for valuable suggestions as well as for help with microscopy and Bert Poolman for valuable discussions. B.V.D.B. is recipient of fellowships from the Fund for Scientific Research, Flanders (FWO; 12O1917N, 12O1922N, V428917N, and 11C6812/4N), from the Federation of European Microbiological Societies (FEMS; RG-2016-0052), from the Belgian American Educational Foundation (BAEF; 2016-E083) and from the European Molecular Biology Organization (EMBO; ALTF 3442017). J.E.M. was granted a fellowship by the Agency for Innovation by Science and Technology (IWT). This work was furthermore supported by grants from FWO (1528318N, G0B2515N and G055517N), KU Leuven (C16/17/006), the Flanders Institute for Biotechnology (VIB) (to J.M. and B.V.D.B), the Deutsche Forschungsgemeinschaft (278002225/RTG 2202) (to T.F.) and from the Dutch Research Council (NWO; VIDI grant 864.11.001) to M.H.


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