Publication:

SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

Date

2024
Journal article
https://doi.org/10.1016/j.neuron.2024.07.007
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dc.contributor.authorVermaercke, Ben
dc.contributor.authorIwata, Ryohei
dc.contributor.authorWierda, Keimpe
dc.contributor.authorBoubakar, Leila
dc.contributor.authorRodriguez, Paula
dc.contributor.authorDitkowska, Martyna
dc.contributor.authorBonin, Vincent
dc.contributor.authorVanderhaeghen, Pierre
dc.contributor.imecauthorRodriguez, Paula
dc.contributor.imecauthorBonin, Vincent
dc.date.accessioned2024-11-26T09:43:54Z
dc.date.available2024-10-10T19:45:31Z
dc.date.available2024-11-26T09:43:54Z
dc.date.embargo2024-08-06
dc.date.issued2024
dc.description.wosFundingTextWe thank members of the P.V. lab and CBD for helpful discussions and precious help. We thank Alexandre Gehanno, Daan Remans, and Arissa Jokhio for precious help. This work was funded by grants from the European Research Council (NEUROTEMPO), the C1 KU Leuven Internal Funds Program, the EOS Program, the Foundation GENERET, ERANET EPINEURO-DEVO, NSC-Reconstruct, the Belgian FWO, and the Belgian Queen Elizabeth Foundation (P.V.). The authors gratefully acknowledge the VIB Bio Imaging Core for their support and assistance in this work. R.I. was supported by a postdoctoral fellowship of the FRS/FNRS.
dc.identifier.doi10.1016/j.neuron.2024.07.007
dc.identifier.issn0896-6273
dc.identifier.pmidMEDLINE:39111306
dc.identifier.urihttps://imec-publications.be/handle/20.500.12860/44622
dc.publisherCELL PRESS
dc.source.beginpage3058
dc.source.endpage3068
dc.source.issue18
dc.source.journalNEURON
dc.source.numberofpages20
dc.source.volume112
dc.subject.keywordsEARLY BRAIN-DEVELOPMENT
dc.subject.keywordsINTELLECTUAL DISABILITY
dc.subject.keywordsCRITICAL-PERIOD
dc.subject.keywordsMATURATION
dc.subject.keywordsPLASTICITY
dc.subject.keywordsMUTATIONS
dc.subject.keywordsCELLS
dc.subject.keywordsSPECTRUM
dc.subject.keywordsAUTISM
dc.subject.keywordsSYNAPSES
dc.title

SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

dc.typeJournal article
dspace.entity.typePublication
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